Glibenklamid merupakan obat antidiabetika golongan sulfonilurea yang umumnya dianalisis dengan metode Kromatografi Cair Kinerja Tinggi (KCKT), kromatografi cair-spektrometri massa, elektroforesis kapiler dan spektrofotometri ultraviolet-visibel. Analisis menggunakan instrumen membutuhkan pretreatment sampel, diantaranya dengan ekstraksi cair-cair dan ekstraksi fase padat atau Solid Phase Extraction (SPE). Salah satu kekurangan SPE yaitu selektivitas metode ini tergantung dari pemilihan penjerap yang didasarkan pada kemampuannya berikatan dengan analit. Kekurangan SPE tersebut diperbaiki dengan teknik Molecularly Imprinted Polymer (MIP). SPE-MIP glibenklamid telah dibuat dengan menggunakan monomer fungsional, asam metakrilat (MAA). Oleh karena itu penelitian ini dilakukan untuk optimasi kondisi pemisahan glibenklamid menggunakan SPE-MIP dengan monomer asam metakrilat yang telah dibuat pada penelitian sebelumnya. Penelitian dilakukan melalui tahapan penyiapan alat dan bahan, optimasi kondisi dan uji kesesuaian sistem KCKT, optimasi kondisi ekstraksi, validasi metode analisis, serta analisis data statistik. Hasil analisis glibenklamid kombinasi metformin yang dipreparasi dengan SPE-MIP monomer asam metakrilat memberikan hasil yang memenuhi persyaratan seperti analisis glibenklamid kombinasi metformin yang dipreparasi dengan SPE C-18. SPE C-18 dan SPE-MIP MAA berbeda nyata dalam memperoleh kondisi optimum ekstraksi glibenklamid. Kata kunci: Asam metakrilat, glibenklamid, KCKT, SPE-MIP

Pengelolaan obat di sarana kefarmasian merupakan kegiatan yang penting di perhatikan karena berhubungan dengan keberlangsungan sarana serta kepuasan pengguna obat. Penggunaan sistem informasi dalam mengelola obat dapat mempermudah pekerjaan serta menjadikan hal tersebut efektif dan efisien. Terutama dalam kegiatan perencanaan dan pengendalian persediaan farmasi. Tujuan penelitian ini adalah membangun sistem informasi dalam perencanaan jumlah obat dan mengendalikan persediaan farmasi di sarana kefarmasian dengan metode EOQ dan ROP. Pembangunan sistem informasi ini menggunakan bahasa pemprograman PHP dan untuk databasenya menggunakan MySQL. Metode yang digunakan dalam aplikasi ini adalah metode waterfall. Kesesuaian hasil perhitungan nilai perencanaan, EOQ dan ROP dibandingkan dengan menggunakan perhitungan melalui excel. Pengujian fungsionalitas aplikasi dilakukan dengan menggunakan blackbox testing kepada beberapa responden. Sistem informasi berbasis web yang telah dibangun memiliki empat menu utama yaitu data obat, stok obat, ramalan perencanaan obat dengan metode konsumsi, pengendalian persediaan dengan metode EOQ ROP. Nilai jumlah perencanan obat, EOQ dan ROP menunjukkan hasil yang sesuai dengan dibandingkan perhitungan menggunakan excel. Sistem informasi berbasis web dapat digunakan dengan baik dan memberikan hasil yang sesuai seperti perhitungan secara manual dan excel.

Diabetes mellitus is a degenerative disease due to impaired cell function β-pancreas in insulin production causing hyperglycemics accompanied by microvascular complications such as diabetic ulcers. This condition is aggravated by bacterial contamination, one of which is Salmonella spp. The use of natural ingredients that have the potential for the treatment of diabetic ulcers is the mangosteen plant (Garcinia mangostana L.), so the identification of Salmonella spp in diabetic ulcers and testing the antibacterial activity of ethyl acetate and n-hexan leaves and mangosteen stem skins is carried out. The method started from the stage of bacterial identification using selective media, gram staining, biochemical testing, and antibacterial activity tests by diffusion of discs. Results showed that Salmonella spp was positif in SSA-specific media, biochemical tests, red bacteria, rod-shaped. Antibiotic sensitivity tests obtained by ciprofloxacin had the strongest activity of 30.20±1.37mm. The largest antibacterial activity result at a concentration of 100% obtained the ethyl acetate fraction of mangosteen leaves is 17.30±0.5mm compared to the fraction of n-hexane leaves of 8.81±0.32mm, ethyl acetate fraction and n-hexan mangosteen stem skin of 13.28±0.95mm, 7.42±0.45mm

Radikal bebas memiliki efek menyebabkan terjadinya kerusakan sel dalam tubuh sebagai pemicu berbagai penyakit. Antioksidan diketahui memiliki kemampuan untuk meredam radikal bebas. Telah dilakukan penelitian potensi aktivitas antioksidan dari ekstrak kental dan fraksi daun kopi robusta (Coffea robusta). Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 70 % selama 3 x 5 hari pada suhu ruangan, diperoleh ekstrak kental dengan rendemen 15,9 % b/b. Fraksinasi dilakukan dengan pelarut berdasarkan perbedaan kepolaran diperoleh fraksi n-heksan, fraksi etil asetat dan fraksi air. Uji antioksidan menggunakan alat Spektrofotometer Uv-Vis dengan metode penghambatan radikal bebas DPPH (2,2-Difenil-1-Pikrilhidrazil) terhadap ekstrak kental dan fraksi n-heksan, etil asetat dan air pada beberapa konsentrasi, yaitu 100 ppm, 80 ppm, 60 ppm, 40 ppm, 20 ppm. Hasil penelitian menunjukkan penghambatan radikal bebas (% Inhibisi) ekstrak dan fraksi meningkat sesuai peningkatan konsentrasi uji. Nilai % Inhibisi ekstrak kental, fraksi n-heksan, fraksi etil asetat dan fraksi air, pada konsentrasi 100 ppm berturut-turut adalah 93,7 %, 95,56 %, 69,54 % dan 61,28 %. Hasil perhitungan IC50 yang diperoleh untuk ekstrak kental adalah 43,83 ppm, fraksi n-heksan adalah 38,32 ppm, fraksi etil asetat adalah 37,07 ppm dan fraksi air adalah 73,62 ppm.

Tuberculosis remains a major public health concern due to emerging cases of drug resistance. To overcome this issue, the effectiveness of antitubercular medications must be reinforced. One of the methods that can be used is using active targeting, which involves small molecules that bind to a specific receptor. In this research, we study the potential of N-hydroxysuccinimide (NHS) folate to be used as the targeting agent against the GAPDH (glyceraldehyde-3-phosphate dehydrogenase) cell-surface receptor, a common virulence factor found on many pathogenic bacteria, including Mycobacterium tuberculosis. We conducted this research using computational methods, specifically molecular docking and molecular dynamics simulation. Based on the evaluation of molecular docking and molecular dynamics simulation results, NHS-folate is predicted to have a huge potential to be an active targeting agent against the GAPDH receptor of Mycobacterium tuberculosis.

Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz locally known as Balik Angin in Borneo Island is one of the endemic plants that have the potential to be an alternative antibacterial agent. Balik Angin leaves contain secondary metabolites that have to play a role to inhibit the growth of Gram-positive bacteria. This study aimed to compare the different extraction solvents which are methanol and ethanol on the maceration of Balik Angin leaves in producing antibacterial activity against Propionibacterium acnes. The leaves were macerated using methanol and ethanol respectively. Antibacterial assay was carried out by the Well diffusion method. The results showed minimum inhibitory concentration (MIC) of ethanol extract which is 3.2% has a diameter of clear zone of 9.475±0.311 mm. Meanwhile, the methanolic extract with a similar MIC has a lower diameter of clear zone of 2.55±0.85 mm. The results correlate with the number of secondary metabolites groups that were identified based on phytochemical screening in ethanol extract containing alkaloid, phenolic, flavonoid, tannin, saponin, and phytosteroid, however, methanol extract not containing alkaloid. The conclusion of this study is ethanol solvent more effective to extract secondary metabolites from Balik Angin leaves compare to methanol solvent, so that can produce more powerful anti-Propionibacterium acnes activity.

The aim of this research was to isolation of mucilage from gedi leaf (Abelmoschus manihot L. Medik) and characterized physicochemical properties. The isolation result was yellowish brown powder that swelling and dissolves slowly in water, but does not dissolve in ethanol, methanol, acetone and ether. The yield is 1.33%. Swelling index value 100% and viscosity 28 ± 2.65 mpas, pH 7.1. Proximate analysis showed 10.46% water content, 38.80% ash, 14.66% protein, 0.69% fat, 35.38% carbohydrate Water holding capacity (WHC) and  oil holding capacity (OHC) of musilago are respectively 4.23 ± 0.18 and 0.65 ± 0.14. Viscosity, Swelling index, WHC and OHC mucilage gedi leaf  may be considered as pharmaceutical excipients.Keywords: Mucilage, Abelmoschus manihot, swelling, viscosity

Monascus purpureus red yeast rice (MpRYR), popularly known as angkak, is a Chinese fermented rice health product. The red pigments and monacolin K contained in MpRYR are sensitive to various factors, including acidity, temperature, oxidation, and light; thus, MpRYR is unstable and susceptible to damage during storage and processing. It was reported that monacolin K in red yeast rice solution was easily degraded under thermal treatment at 85–121°C, and the absorbance of MpRYR extract increased at an alkaline pH. This work aimed to study the effects of pH on the stability of pigment extract  MpRYR. MPRYR was purchased from Raja Godhong herbal supplier and extracted with 70% ethanol for 3 × 24 h. The resulting MpRYR extracts were subjected to various pH conditions, and the pH and absorbance were measured, and the degradation rate of MpRYR extracts was calculated. The initial pH of MpRYR extract is 5.75, which increased to 5.97 (+3.82%) at 3 h. The MpRYR extract was more stable in an acidic medium with a degradation rate of 3.80% at 3 h. Research results suggest that acidic conditions are preferable for storing and formulating MpRYR-based products to preserve their functional efficacy.

Kesambi (Schleichera oleosa) merupakan salah tanaman asli Indonesia yang berpotensi sebagai obat dan memiliki senyawa aktif yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui potensi berbagai bagian tanaman sebagai antioksidan dengan metode DPPH. Simplisia diekstraksi dengan metode maserasi menggunakan pelarut etil astetat. Identifikasi golongan senyawa dilakukan dengan skrining fitokimia menggunakan reagen kimia sedangkan pengujian aktivitas antioksidan dilakukan dengan metode peredaman radikal DPPH menggunakan spektrofotometer pada panjang gelombang 515 nm. Hasil skrining fitokimia menunjukkan bahwa semua ekstrak etil asetat dari berbagai bagian tanaman mengandung senyawa flavonoid, fenolik dan tannin. Pengujian aktivitas menunjukkan ekstrak etil asetat daun kesambi memiliki aktivitas antioksidan paling baik dengan nilai IC50 5,4952 μg/mL, dibandingkan dengan kulit batang (14,3621 μg/mL), akar (43,4159 μg/mL), kulit buah (159,8782 μg/mL) dan daging buah (167,2912 μg/mL). Ekstrak etil asetat berbagai bagian tanaman kesambi memiliki aktivitas antioksidan dengan urutan paling baik yaitu daun, kulit batang, akar, kulit buah, dan daging buah. Adanya profil bioaktivitas tersebut dapat memberikan informasi tambahan terhadap kekuatan atioksidan pada berbagai bagian tanaman kesambi yang belum dilaporkan pada penelitian sebelumnya sehingga dapat dikembangkan untuk penelitian lebih lanjut.

Most degenerative diseases are linked to excess free radicals generated by the body's metabolism or exposure to external factors. Antioxidants are used to help neutralize free radicals and treat bacterial infections. Andiroba bark (Carapa guianensis) is one of the plants used empirically by the people of the Province of Jeneponto to treat various diseases. This study aims to determine whether the ethanol extract of andiroba bark meets the standardization requirements and exhibits antioxidant activity, and to identify its ability to inhibit the growth of Staphylococcus aureus, Propionibacterium acnes, Staphylococcus epidermidis, and Escherichia coli. The results of the research showed that the results of specific and non-specific standardization of the ethanol extract from andiroba bark met the specified requirements, the ethanol extract had an antioxidant activity with an IC50 value of 15.985 μg/mL, which was included in the group of very strong antioxidants and could inhibit the growth of Staphylococcus aureus, Propionibacterium acnes, Staphylococcus epidermidis, and Escherichia coli bacteria at concentrations of 0.01 g/mL, 0.05 g/mL, and 0.1 g/mL. Overall, the ethanol extract from andiroba bark meets the standardization requirements and exhibits antibacterial activity.

Sweet orange contains flavonoids and citric acid that have the potential as a capping agent in the nanosilver biosynthesis process. The antibacterial activity of silver can be increased in nanoparticles, then it can be applied to treat acne through a peel-off mask preparation. Glycerin and Polyethylene glycol 400 are humectants that combined to obtain good physicochemical properties of the preparation. This study aims to determine the character of nanosilver biosynthesis and the effect of humectant combination on the physicochemical properties of the preparation. The characterization of nanosilver was employed by UV-VIS Spectrophotometry, Particle Size Analysis, and Scanning Electron Microscope. The Glycerin- PEG 400 combination was F1 (0:100%); F2 (25:75%); F3 (50:50%); F4 (75:25%) and F5 (100:0%). The results of nanosilver biosynthesis have an absorption peak of nanoparticles at 421-423nm, rod shape, the particle size of 83.2±7.2nm. Statistical analysis showed that the combination of Glycerin- PEG 400 had a significant effect on organoleptic, viscosity, and dry time, but did not affect the pH of preparation. The combination of Glycerin-PEG 400 (75%:25%) is the best formula because it has stable viscosity, dry time, and pH value during storage for four weeks.Keywords: nanosilver, biosynthesis, Citrus sinensis, humectants, peel off mask

Benalu mangga (Dendrophthoe petandra L. Miq.) merupakan obat tradisional yang dapat berkembang menjadi obat herbal terstandar. Pembuktian secara ilmiah mengenai keamanannya penting untuk diketahui, salah satu caranya melalui uji toksisitas akut. Penelitian ini bertujuan untuk mengetahui nilai toksisitas akut (LD50), tingkat keamanan ekstrak etanol herba benalu mangga, dan gejala klinis yang ditimbulkannya. Mencit dibagi dalam kelompok kontrol dan kelompok uji dengan lima variasi dosis (4, 8, 16, 32, 64 g/kg berat badan mencit) diberikan secara per oral. Hasil penelitian menggunakan metode analisis probit pada mencit jantan dan betina menunjukkan tingkat keamanan ekstrak etanol herba benalu mangga tidak toksik berdasarkan klasifikasi toksisitas Harmita dan Radji, yakni berada pada rentang dosis > 15 g/kg berat badan tikus. LD50 mencit jantan sebesar 34,28 g/kg berat badan atau setara dengan dosis 23,99 g/kg berat badan tikus, sedangkan pada mencit betina sebesar 22,41 g/kg berat badan atau setara dengan dosis 15,69 g/kg berat badan tikus. Hasil skrining farmakologi menunjukkan bahwa ekstrak etanol herba benalu mangga menimbulkan pengaruh pada sistem saraf pusat yaitu menurunkan efek retablismen dan gelantung pada mencit jantan, serta memberikan efek katalepsi pada mencit betina.Kata kunci: Ekstrak etanol Dendrophthoe pentandra L. Miq., toksisitas akut, nilai LD50

The field of nanotechnology focuses on systems at the nanometer scale. Nanotechnology is used in the medical field for drug development, medical imaging, and gene therapy. One application of nanotechnology is nanoparticles. Nanoparticles have sizes in the nanometer range, with a scale of 1 to 100 nm. Nanoparticles can be designed to stimulate the immune system and improve the immune response. Literature study using research articles from national and international journals the application Publish or Perish 8 based on the keywords "Immunostimulants, Nanotechnology, nanoparticle, gold nanoparticle, and silver nanoparticle." Based on searching various literature studies, it is proven that nanoparticle preparations can increase immunostimulants with various testing instruments that are often found, namely FTIR (Fourier Transform Infrared), WHICH (Scanning Electron Microscopy), XRD (X-ray Diffraction), HE HAS (Transmission Electron Microscopy), particle size, zeta potential, and spectroscopy UV-visible. Nanoparticles can be an effective drug delivery system and can help maintain the immune system in the body.

Mosquitoes can carry protozoa, viruses, and worm larvae that can cause various diseases in humans.Mosquito repellent preparations that are widely sold in the market are in the form of lotion preparations.However, most formulas of mosquito repellent products on the market contain DEET (N, N-diethylmeta-toluamide) which has side effects such as symptoms of hypersensitivity, irritation, and urticaria.Male palm flower (Elaeis guineensis Jacq.) is a natural material that contains flavonoid and estragolecompounds that have activity as a mosquito repellent. Therefore, this study aimed to determinethe lotion activity of male palm flower extract (Elaeis guineensis Jacq.) as an insect repellent. Theprocedure steps in this study include sample preparation, extract making, and lotion formulation withextract concentrations of F1(1%), F2(2%), F3(3%), F4(4%), and F5(5%), evaluation of physicalproperties, test stability and test the protection power of the lotion against mosquitoes. The results ofthe physical properties test showed that the lotion preparation was in the appropriate range with thespecified parameters and was stable at room temperature storage. The results of the effectiveness testshowed that the most effective formula was the F5 which has the best physical properties and a verystrong protective power.

Anthocyanin is active compound of purple sweet potato, has effect as anti-oxidative, anti-inflammatory, and anti-itching, make them interesting ingredients for skin treatment. The body scrub is one of popular cosmetic product in SPA industry. Their stability property is one crucial factor to develop a purple sweet potato body scrub cream. The steam and oven heating of tuber were involved on the scrub powder preparation.The oven and non-heating preparation scrub powder provided fine-sized powder more than 50%, but the steaming produced granular particle distribution. Total anthocyanin content in scrub grains was 326.8 mg/100 g for steam preparation, 103.3 mg/ 100 g for oven, and 34.4 mg/100g for non-heating, respectively. The steamed scrub powder preparation method produced stabile anthocyanin content in body scrub cream for 25 days observation.

Kestabilan lereng merupakan aspek yang perlu diperhatikan dalam tambang batubara terbuka Asam Asam untuk mencegah terjadinya kelongsoran. Kestabilan lereng dapat dipelajari menggunakan analisis kesetimbangan batas yang didasarkan dari teori Mohr–Coulomb Failure Criterion untuk mengetahui respons dari material batuan terhadap suatu gaya yang diberikan. Dari analisa tersebut tingkat kestabilan di lereng pertambangan dapat dikuantifikasi dengan mengukur nilai faktor keamanan (FK) dari sebuah lereng. Pada penelitian ini, penulis melakukan analisis kestabilan lereng pada tiga desain lereng highwall tambang batu Bara terbuka Asam Asam di Pit “X” yang dioperasikan oleh PT. Arutmin Indonesia, dengan bantuan perangkat lunak Geostudio SLOPE/W dan metode perhitungan nilai kesetimbangan batas Morgenstern–Price. Analisis pada ketiga lereng menunjukkan bahwa faktor keamanan dari desain lereng masih relatif tinggi dibanding standar perusahaan, sehingga penulis dapat memberi rekomendasi berupa optimasi desain. Optimasi desain lereng tambang bertujuan untuk mengurangi jumlah material yang tidak diinginkan namun masih memperhatikan nilai standar faktor keamanan dari tiap lereng. Penulis menemukan bahwa memungkinkan dilakukan optimasi dari ketiga lereng dengan mengurangi lebar bench tiap lereng dari 10 meter menjadi 7 meter, sehingga pengurangan lebar bench membuat sudut keseluruhan masing-masing lereng menjadi semakin tegak dengan kenaikan sudut sebesar 4o. Dengan dilakukannya optimasi, maka pihak perusahaan dapat mengurangi jumlah material yang tidak diinginkan dalam proses pengupasan, sehingga dapat mengurangi waktu dan biaya yang dibutuhkan dalam kegiatan ekstraksi batu bara.

Landslides are a common natural disaster in Indonesia, especially in Banyuresmi Village, Sukasari District, Sumedang Regency, which is a research area covering 9.58 . This study aims to identify landslide vulnerability zones using the Analytical Hierarchy Process (AHP) method. This method is used in decision making by compiling a process hierarchy structure, a pairwise comparison matrix, class and subclass weighting analysis, and a consistency ratio (CR) test. The method was applied to evaluate and spatially overlay the controlling factors of landslide vulnerability, namely slope gradient, lithology, aspect (slope direction), land cover, and distance from streams. The results showed that the study area was predominantly classified as having moderate to high vulnerability, with the high vulnerability zone covering 60.94% of the area, the moderate vulnerability zone covering 38.38%, and the low vulnerability zone covering only 0.68%. Slope gradient was identified as the dominant factor, followed by lithology and aspect. Field validation confirmed a strong spatial correlation between the mapped high-risk zones and the actual locations of reported landslides, demonstrating the reliability of the method through field validation. Overall, this study provides a scientific basis and recommendations for land use planning, minimizing the risk of landslides, and mitigation strategies, especially in residential areas in Banyuresmi Village.Keywords: Analytical Hierarchy Process, Banyuresmi, Landslide, Sumedang, Slope

Administratively, Tanjungsari and its vicinity area lies within Bogor Subprovince, West Java – Indonesia. According to Java’s physiographic map by Van Bemmelen (1949), this area can be included as a part of the Bogor Zone. The goal of this research is to analysis samples of sandstone from Jatiluhur Formation and Cantayan Formation due to know the provenance of the formation. Sandstone from Jatiluhur Formation is Feldspathic Wacke and sandstone from Cantayan Formation is Lithic Arenite based on the sandstone classification by Pettijohn, 1975. According to the grain composition, the provenance of Jatiluhur Formation is the plutonic igneous rock, it shown by the quartz grain dominated by monocrystaline grain with non-undulatory extinction. Feldspar is dominated by Potassium Feldspar.  While the Cantayan Formation came from volcanic igneous rock, known by the abundance of igneous rock fragment with afanitic texture. The quartz grain is the less, consist of monocrystaline quartz with non – undulatory extinction. Based on the tectonic setting of the source rock, sandstone from Jatiluhur and Cantayan Formation came from the rock that part of Magmatic Arc area which the sediment source of Jatiluhur Formation is from Dissected Arc, while Cantayan Formation is from Transitional Arc – Undissected Arc area. Keyword:    Tanjungsari, Jatiluhur Formation, Cantayan Formation, sandstone, provenance. Secara administratif, daerah Tanjungsari dan sekitarnya termasuk kedalam wilayah Kabupaten Bogor, Propinsi Jawa Barat, dan terletak di dalam Zona Bogor menurut pembagian fisiografi oleh Van Bemmelen (1949). Tujuan penelitian ini yaitu melakukan analisis pada contoh batupasir Formasi Jatiluhur dan Formasi Cantayan guna mengetahui sumber sedimen pembentuk formasi tersebut. Batupasir Formasi Jatiluhur termasuk jenis Feldspathic Wacked dan batupasir Formasi Cantayan termasuk jenis Lithic Arenite berdasarkan klasifikasi batupasir oleh Pettijohn, 1975. Dari komposisi sedimen yang diamati, Formasi Jatiluhur berasal dari batuan beku plutonik ditunjukkan oleh butir kurasa yang didominasi oleh butiran monokristalin dengan sudut pemadaman lurus. Jumlah butir feldspar didominasi oleh K feldspar. Sedangkan batupasir Formasi Cantayan berasal dari batuan beku vulkanik, diketahui dari jumlah fragmen batuan yang sangat banyak berupa batuan beku bertekstur halus. Jumlah butir kuarsa ditemukan sangat sedikit berupa kuarsa monokristalin dengan sudut pemadaman lurus. Berdasarkan tatanan tektonik batuan sumber, batupasir Formasi Jatiluhur dan Formasi Cantayan  berasal dari batuan yang berada pada tatanan tektonik busur magma (Magmatic Arc) yang mana Formasi Jatiluhur bersumber dari area Dissected Arc, sedangkan Formasi Cantayan berasal dari area Transitional Arc – Undissected Arc. Kata kunci: Tanjungsari, Formasi Jatiluhur, Formasi Cantayan, batupasir, sumber sedimen.

Fuel needs that keeps on increasing in Makasar can not be fullfilled by the Makasar installation, therefore it is necessary to built Bau-Bau Transit Terminal in Southeast Sulawesi Province.The construction will raise effects towards environment. Hence the needs of EIA study is very crucial to minimize all the effects that will appear in the future to support sustainable development.

The northern part Cianjur based on the Regional Hazard Map of Mount Gede in West Java (kaswanda, 1994) is an explosion hazard areas. The rapid economic development, especially in the tourism sector resulting in increased occupancy, hotel or villa. As a result of the growth area of the building, and the increase of population, and transfer of land use, has resulted in the handling of the impact so that the necessary pre-disaster management in which one of them is a disaster mitigation. Determination of the level of risk is one basis for determining mitigation measures related to spatial planning. The main risk factors of natural disasters include volcanic eruption hazard factors, vulnerability and resilience. Factors will affect the hazard mitigation measures that will be done in the danger area. The primary hazard mitigation in the area would have been different in the secondary area. Thus the delineation is an important step that must be done before determining the level of risk. Determination of the spatial areas prone to natural disasters Volcanic eruptions, can be done with the mitigation measures related to spatial planning based on risk level.